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KMID : 0605720150210020081
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Journal of the Korean Society of Biological Therapies in Psychiatry
2015 Volume.21 No. 2 p.81 ~ p.94
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Biomarkers in Depression
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Kim Hye-Guem
Cheon Eun-Jin
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Abstract
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Depression is one of the most common psychiatric disorders that is associated with high level of disability, morbidity and mortality. Depression is a heterogeneous disorder, and it seems to be the result of complex interaction of several factors including genetic and environmental factors. Numerous studies have reported available biomarkers in depression, which is detectable biological character reflecting pathogenic process or treatment response. They include neuroendocrine system such as hypothalamic-pituitary-adrenal axis, inflammatory markers, neurotrophic factors, fatty acid markers, sleep factors, structural brain images and functional brain images. Understanding biomarkers is essential for classifying the clinical features of depression and subsequently help determine individualized treatment for each subgroup. This article reviewed literatures about biomarkers in depression, in order to reconsider potential clinical use of it.
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KEYWORD
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Depression, Biomarker, Neurobiology
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